Ouu, two in a day, you can tell I’m avoiding studying
What it is: analgesic (pain killer), anti-inflammatory, antipyretic (lowers fever)
Indications: Pain, inflammation, fever
Mechanism of action: Ibuprofen is a non-selective COX inhibitor, meaning that it blocks both COX-1 and COX-2. By blocking COX (any immature thoughts there?), ibuprofen blocks prostaglandin (particularly PGE2) production. PGE2 causes a lot of the nasty side effects associated with injury like pain and inflammation because it brings in all of the inflammatory cells and can make pain neurons fire even more. As a side note, COX-1 is floating around the body most of the time anyways, particularly in the gut, while COX-2 is thought to only be around when there’s inflammation. This is why people who take ibuprofen or aspirin for a long time end up getting ulcers (the body needs the COX-1 in the stomach) and why scientists thought it would be an excellent idea to make selective COX-2 inhibitors like celecoxib (Celebrex). While COX-2 inhibitors don’t cause as many gastrointestinal problems, they’ve been shown to have a bunch of other nasty side effects such as cardiotoxicity (this is why Vioxx no longer exists).
Interactions: Not a whole lot, but people with kidney disease might watch out for ibuprofen
Adverse effects: GI ulcers
I might need some ibuprofen now since Wii boxing kicked my butt last night and now my shoulders are sore.